Chromatin Accessibility Analysis

The assay for transposase-accessible chromatin with sequencing (ATAC-seq) is a method for determining chromatin accessibility. An ATAC-seq experiment infers nucleosome positions and provides valuable insights into a wide range of regulatory elements such as transcription factor binding sites, promoters, enhancers, and insulators. Differential analysis of chromatin accessibility among multiple samples (tissues, cells, or individuals in case–control studies) could help to identify open chromatin regions of regulatory elements involved in gene transcription events.